Functional connectivity in brain networks underlying cognitive control in chronic cannabis users

IH Harding; N Solowij; BJ Harrison; M Takagi; V Lorenzetti; DI Lubman; ML Seal; C Pantelis; M Yücel

Journal article

Functional connectivity in brain networks underlying cognitive control in chronic cannabis users

IH Harding, N Solowij, BJ Harrison, M Takagi, V Lorenzetti, DI Lubman, ML Seal, C Pantelis, M Yücel

Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2012

DOI: 10.1038/npp.2012.39

Abstract

The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control abilities are thought to have a major role in everyday functioning, and their dysfunction has been implicated in the maintenance of maladaptive drug-taking patterns. In this study, the Multi-Source Interference Task was employed alongside functional magnetic resonance imaging and psychophysiological interaction methods to investigate functional interactions between brain regions underlying cognitive control. Current cannabis users with a history of greater than 10 years of daily or near-daily cannabis smoking (n=21) were compared with age, gender, and IQ-matched no..

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University of Melbourne Researchers

Ben Harrison Author

Marc L Seal Author

Christos Pantelis Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by funding from the National Health and Medical Research Council of Australia (NHMRC; Project Grant 459111). NS is supported by an Australian Research Council Future Fellowship (FT110100752). MY is supported by a NHMRC Fellowship Award (Grant 1001973). BJH is supported by an NHMRC Clinical Career Development Award (628509). CP is supported by an NHMRC Senior Principal Research Fellowship (Grant 628386) and NHMRC Program Grant (Grant 566529). DL has received a speaking honorarium from Astra Zeneca Pharmaceuticals, and CP has provided consultancy for Janssen-Cilag, Eli Lilly, Hospira (Mayne), and Astra Zeneca, Pfizer, Schering Plough, and Lundbeck, and has undertaken investigator-initiated studies supported by Eli Lilly, Hospira, Janssen Cilag, and Astra Zeneca. These activities are unrelated to the present work. Otherwise, except for income received from our primary employers and funding bodies listed in Acknowledgements, no financial support or compensation has been received from any individual or corporate entity over the past three years for research or professional service and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest.